Fibrous dysplasia of the skull, with seizures and focal electroencephalographic findings.

Introduction Fibrous dysplasia is a non-hereditary disease of childhood, of unknown etiology, in which fibrous tissue replaces normal bone. There is a wide spectrum of involvement, from asymptomatic isolated bonelesions to severe debilitation and the rare Albright’s syndrome of osteitis fibrosa disseminata, hyperpigmented skin lesions and endocrine dysfunction (Albright et al. 1937). The following case demonstrates how closely fibrous dysplasia may resemble an intracranial malignancy, both clinically and electroencephalographically . Although seizures have been noted in prior reports (e.g. Sassin and Rosenberg 1968), electroencephalographic features of fibrous dysplasia have not been described previously.